HEREDITARY COAGULATION INHIBITOR ANTITHROMBIN-III DEFICIENCY

The importance of AT III (antithrombin III) determination, because of its biological role, was discussed Deficit of AT III represents the ri sk factor for thrombosis and thromboembolism. In the case of recurrent venous thrombosis, unusual localization, in early life, one may suspe ct acquired or inherited coagulation inhibitor disorder, such as antit hrombin III, protein C or some else. The level of AT III needn't be ve ry low. Some trigerring mechanisms can precipitate thrombosis also in asymptomatic subjects, with decreased AT III Level. Here we present on ly a part of our more extensive study Now we have two families of AT I II deficient patients, under investigations. Possibilities for treatme nt of patients and problems with asymptomatic AT III deficient subject s were mentioned.