EFFECT OF DL-SODIUM LACTATE INFUSION ON EXCRETION OF PURINE-BASES ANDOXYPURINOL

To investigate whether or not DL-sodium lactate inhibits the renal exc retion of purine bases and oxypurinol, we administered physiological s aline containing 0.2 mol DL-sodium lactate to 7 normal subjects intrav enously. DL-sodium lactate infusion decreased the urinary excretion an d the fractional clearance of uric acid, xanthine and oxypurinol, but the fractional clearance of hypoxanthine was not affected. These resul ts suggested that the implications of DL-sodium lactate-induced hyperu ricemia must be considered in patients with gout on its long term and high dose administration, and that the implications of DL-sodium lacta te-induced prolongation of half-life of oxypurinol must be considered in hyperuricemic patients treated with allopurinol. However, since the high dose and long term administration of DL-sodium lactate is clinic ally rare, the effect of DL-sodium lactate infusion on the urinary exc retion of uric acid, xanthine and oxypurinol may not be clinically imp ortant.