EFFECTS OF SNUFF ON REGIONAL BLOOD-FLOW TO THE CHEEK AND TONGUE OF ANESTHETIZED DOGS

Authors
HUCKABEE KD BARNES RT WILLIAMS AG FAN WL DOWNEY HF
Citation
Kd. Huckabee et al., EFFECTS OF SNUFF ON REGIONAL BLOOD-FLOW TO THE CHEEK AND TONGUE OF ANESTHETIZED DOGS, Oral surgery, oral medicine, oral pathology, 76(6), 1993, pp. 729-735
Citations number
20
Categorie Soggetti
Pathology,Surgery,"Dentistry,Oral Surgery & Medicine
Journal title
Oral surgery, oral medicine, oral pathology → ACNP
ISSN journal
00304220
Volume
76
Issue
6
Year of publication
1993
Pages
729 - 735
Database
ISI
SICI code
0030-4220(1993)76:6<729:EOSORB>2.0.ZU;2-S
Abstract
Regional blood flow to the cheek and tongue of anesthetized dogs was m easured before and after application of six different doses of snuff ( 3.12 to 100 mg/kg body weight) to the right cheek. Dose-independent va sodilation was observed at the site of application, whereas dose-depen dent vasoconstriction was observed contralaterally. Aortic, central ve nous, and ventricular pressures were significantly increased (p < 0.05 ) at the higher doses. Plasma nicotine concentrations increased stepwi se with dose.