THROMBOLYTIC TREATMENT AND BALLOON ANGIOPLASTY IN CHRONIC OCCLUSION OF THE AORTIC BIFURCATION

Objective: To evaluate nonsurgical alternatives in reopening chronical ly occluded aortic bifurcation. Design: Uncontrolled randomized study. Setting: University-affiliated referral center for vascular diseases. Patients: Twenty-five of 39 consecutive patients with chronic aortoil iac disease including a totally occluded aortic bifurcation were found to be acceptable candidates for an aortobifemoral prosthetic graft. I ntervention: Patients were randomly assigned to receive either strepto kinase or urokinase or recombinant tissue-type plasminogen activator ( rt-PA). In cases of successful thrombolysis and residual obstructions, subsequent balloon angioplasty was attempted. Prosthetic bypass graft ing was done if thrombolytic treatment and balloon angioplasty failed. Results: Complete lysis was achieved in 5 of 25 patients (20%). In 10 (40%) patients, lysis showed residual obstructions, which were reopen ed mechanically in 8 patients; 2 patients had extra-anatomical bypass grafts. Ten patients (40%) without thrombolysis had surgical aortobife moral bypass grafts. Overall, recanalization and clinical improvement were achieved in 13 of 25 patients (52%) by thrombolytic therapy and s ubsequent balloon angioplasty. The recanalization rate did not differ among the different thrombolytic drugs. However, rt-PA therapy resulte d in reopening after 4 days of treatment; streptokinase, after 6 days; and urokinase, after 9 days (P < 0.005). No major complications or de aths occurred. Conclusion: Thrombolytic treatment followed by balloon angioplasty may help avoid the need for aortobifemoral prosthetic bypa ss grafting in more than 50% of patients with chronic aortoiliac disea se.