THE HUMAN GENE FOR WATER CHANNEL AQUAPORIN-1 (AQP1) IS LOCALIZED ON CHROMOSOME-7P15-]P14

Authors
DEEN PMT WEGHUIS DO VANKESSEL AG WIERINGA B VANOS CH
Citation
Pmt. Deen et al., THE HUMAN GENE FOR WATER CHANNEL AQUAPORIN-1 (AQP1) IS LOCALIZED ON CHROMOSOME-7P15-]P14, Cytogenetics and cell genetics, 65(4), 1994, pp. 243-246
Citations number
21
Categorie Soggetti
Cytology & Histology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
65
Issue
4
Year of publication
1994
Pages
243 - 246
Database
ISI
SICI code
0301-0171(1994)65:4<243:THGFWC>2.0.ZU;2-O
Abstract
The chromosomal localization of the gene encoding aquaporin 1 (previou sly called CHIP28), which acts as a water channel in erythrocytes and in the renal proximal tubules and descending limbs of Henle, was deter mined. Southern blot hybridizations on chromosomal DNA of a panel of 2 5 different human x rodent hybrid cell lines localized the aquaporin 1 gene to human chromosome 7. Additionally, in situ hybridization on R- banded metaphase chromosomes sublocalized the aquaporin 1 gene (AQP 1) to 7p15 --> p14, and some sequence-tagged sites in this region were i dentified.