THE HUMAN GENE FOR NUCLEAR-PROTEIN BM28 (CDCL1), A NEW MEMBER OF THE EARLY S-PHASE FAMILY OF PROTEINS, MAPS TO CHROMOSOME BAND 3Q21

BM28, a newly recognized human nuclear protein, possibly plays an impo rtant role in two crucial steps of the cell cycle e.g. the onset of DN A replication and cell division. It shows significant similarity to me mbers of a recently defined family of early S-phase proteins. Using to tal plasmid DNA containing the complete coding sequence of the BM28 ge ne (CDCL1, for cdc-like 1) as a probe for fluorescence in situ hybridi zation, we have mapped the gene to chromosome band 3q21. This region i s involved in specific structural chromosome aberrations found in acut e myeloid leukemia (AML). Based on the function of BM28 and the chromo somal location of its gene, CDCL1 might prove to be a candidate for an oncogene affected by the chromosomal breaks and playing a pathogeneti c role in AML.