De. Schuller et al., INTENSIFIED REGIMEN FOR ADVANCED HEAD AND NECK SQUAMOUS-CELL CARCINOMAS, Archives of otolaryngology, head & neck surgery, 123(2), 1997, pp. 139-144
Objective: To devise an intensified treatment regimen for patients wit
h advanced, resectable head and neck squamous cell carcinomas. Design:
Phase I/II clinical trial consisting of perioperative cisplatin chemo
radiotherapy, surgical resection, intraoperative radiotherapy, and pos
toperative cisplatin chemoradiotherapy. Setting: The Ohio State Univer
sity Comprehensive Cancer Center, Columbus. Patients: Thirty-seven pat
ients (median age, 63 years) with advanced oral cavity, oropharyngeal,
or hypopharyngeal carcinomas. Results: The range of time at risk was
1 to 30 months (median, 21 months). Thirty of the 37 registered patien
ts were analyzable; 11 have died (5 with distant metastases; 1 of lung
carcinoma; and 5 were cancer-free); 2 experienced second primary tumo
rs in the oral cavity (out of or adjacent to the previous radiotherapy
portals). Treatment compliance was excellent (92%), morbidity was low
, and excellent locoregional control was achieved. Conclusions: The in
itial results are encouraging; the future strategy will intensify the
systemic component of therapy based on results from concurrent laborat
ory studies.