PULMONARY SARCOID-LIKE GRANULOMATA IN A PATIENT TREATED FOR EXTRAPULMONARY HODGKINS-DISEASE

We report a case of interstitial lung disease developing during treatm ent with chlorambucil, vinblastine, procarbazine and prednisone for ex trapulmonary Hodgkin's disease. Transbronchial biopsies demonstrated n oncaseating epithelioid cell granulomata, and bronchoalveolar lavage f luid showed an increased percentage of lymphocytes, with a raised T ce ll helper-suppressor ratio, suggesting a diagnosis of sarcoidosis. Tre atment with corticosteroids brought about complete resolution of the r adiographic lesions. A possible relationship between sarcoidosis and l ymphoma is discussed, and a short review of the literature is given. T his case report has some unique features that, to our knowledge, have not been published before.