CYP 2D6 PM PHENOTYPE HYPOTHESIS OF ANTIDEPRESSANT EXTRAPYRAMIDAL SIDE-EFFECTS

Extrapyramidal symptoms occur as side-effects of neuroleptics. For man y years, case reports of such side-effects, linked to antidepressant t reatments, have been published, but this phenomenon is not well known. Tricyclic and serotonergic antidepressants are both involved. The aut hors present an hypothesis which provides one possible neurobiochemica l explanation for the aetiology of these side-effects. The proposed ex planation is related to the inhibition of the CYP 2D6 isoenzyme by ant idepressants (or neuroleptics) that may be involved in the genesis of the observed extrapyramidal side-effects.