Background. Agenesis of one or more lacrimal puncta is a rare cause of
presentation to ophthalmologists. Where normal canalicular tissue lie
s within the lid, it may occasionally be successfully exteriorized to
the conjunctival surface with relief of symptoms. The pattern of punct
al agenesis, its relationship to the presence of underlying canalicula
r tissue, and its management have not been defined previously in a lar
ge cohort. Methods: The authors reviewed the pattern of agenesis, unde
rlying anatomic abnormalities and patient symptomatology in 57 patient
s seen over a 10-year period. A management plan was devised for eyes w
ith no puncta and those with a single missing punctum. Results: Both p
uncta were absent in 53 eyes, and a single punctum was missing in 41 e
yes. In 86% of eyes with absence of both puncta, no canalicular tissue
was identified when the lacrimal sac was opened at surgery. The under
lying canaliculus also was absent in patients with one absent punctum.
Nasolacrimal duct obstruction frequently accounted for the onset of s
ymptoms in patients with a single punctum. Fifty-three (93%) of the 57
operated eyes were functionally cured at the completion of this repor
t. Conclusion: Punctal agenesis usually is associated with the absence
of underlying canalicular tissue. Where both puncta are absent, the a
uthors recommend inspection of the internal opening of the common cana
liculus at surgery and, if no canalicular tissue can be identified (86
% in this series), insertion of a Lester-Jones tube. Symptomatic patie
nts with a single punctum frequently require surgery to relieve nasola
crimal rather than canalicular obstruction.