LINKAGE ANALYSIS OF A COMPLEX DISEASE - APPLICATION TO FAMILIAL ALZHEIMERS-DISEASE

Authors
NEUMAN RJ RICE JP HAMPE CL BURROUGHS TE MOLDIN SO
Citation
Rj. Neuman et al., LINKAGE ANALYSIS OF A COMPLEX DISEASE - APPLICATION TO FAMILIAL ALZHEIMERS-DISEASE, Genetic epidemiology, 10(6), 1993, pp. 419-424
Citations number
9
Categorie Soggetti
Genetics & Heredity","Public, Environmental & Occupation Heath
Journal title
Genetic epidemiology → ACNP
ISSN journal
07410395
Volume
10
Issue
6
Year of publication
1993
Pages
419 - 424
Database
ISI
SICI code
0741-0395(1993)10:6<419:LAOACD>2.0.ZU;2-Y
Abstract
Evidence for linkage of the Alzheimer's gene to markers on chromosomes 19 and 21 was assessed using single-locus and two-locus models of inh eritance. Families were divided into groups determined by their averag e age at onset. The youngest group produced higher lod scores for mark ers on chromosome 21 while an older group showed evidence for linkage to markers on chromosome 19. Two-locus models of disease were used to analyze the youngest group for linkage to pairs of markers on chromoso me 21 and an older group with markers on chromosome 19. (C) 1993 Wiley -Liss, Inc.