2-LOCUS AND BIVARIATE SEGREGATION ANALYSIS OF HDL-C AND APO-AI

Two-locus and bivariate segregation analyses of HDL-C and apo AI were carried out using the GAW8 Berkeley data set. For HDL-C, results are a mbiguous. Both the mixed environmental model and the mixed Mendelian m odel fit the data equally well. For apo Al, however, univariate one-lo cus segregation analysis suggests a Mendelian major gene controlling i ts levels. Moreover, two-locus analysis suggests a second major gene i s involved. Bivariate segregation analysis indicates these data cannot resolve the question as to whether a single Mendelian major gene with pleiotropic effects controls levels of both HDL-C and apo AI in human s. (C) 1993 Wiley-Liss, Inc.