SMOKING-HABITS AND THE ACQUISITION OF METRONIDAZOLE RESISTANCE IN PATIENTS WITH HELICOBACTER-PYLORI-RELATED GASTRITIS

Authors
WITTEMAN EM HOPMAN WPM BECX MCJM DEKONING RW TYTGAT GN JANSSEN AJHM JANSEN JBMJ
Citation
Em. Witteman et al., SMOKING-HABITS AND THE ACQUISITION OF METRONIDAZOLE RESISTANCE IN PATIENTS WITH HELICOBACTER-PYLORI-RELATED GASTRITIS, Alimentary pharmacology & therapeutics, 7(6), 1993, pp. 683-687
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Alimentary pharmacology & therapeutics → ACNP
ISSN journal
02692813
Volume
7
Issue
6
Year of publication
1993
Pages
683 - 687
Database
ISI
SICI code
0269-2813(1993)7:6<683:SATAOM>2.0.ZU;2-3
Abstract
Thirty-three dyspeptic patients with colonization of Helicobacter pylo ri in the gastric antrum were treated with tripotassium dicitrate bism uthate 120 mg q.d.s. for 28 days and metronidazole 250 mg q.d.s for 10 days starting on day 19. Five weeks after cessation of this treatment regimen H. pylori was eradicated in 23 patients. In 8 of the remainin g 10 patients, H. pylori had become resistant to metronidazole. In thi s study resistance was significantly associated with smoking habits, b ut not with age, bacterial load, gastritis score or alcohol consumptio n.