REDUCTION IN URINARY PROSTAGLANDIN EXCRETION IN THE PREMENSTRUAL-SYNDROME

The purpose of the present work was to study some factors involved in renal handling of salt and water in the premenstrual syndrome (PMS), i n which salt and water retention is frequently observed. In 18 women w ith PMS and in 18 healthy women we studied the levels of cyclic adenos ine monophosphate, aldosterone, prostaglandin E2, prostaglandin F2alph a and kallikrein in urinary samples collected during the luteal phase. There was no difference between the two groups regarding sodium, aldo sterone and kallikrein urinary excretion. In the PMS group there was a significant reduction in urinary excretion of cyclic adenosine monoph osphate, prostaglandin E2 and prostaglandin F2alpha with respect to th e control group. At multivariate analysis sodium urinary excretion pro ved not to be the same as the model validated in healthy women. There may be different renal handling of water and electrolytes during the l uteal phase of the menstrual cycle in women with PMS.