SENSOP - A DERIVATIVE-FREE SOLVER FOR NONLINEAR LEAST-SQUARES WITH SENSITIVITY SCALING

Citation
Is. Chan et al., SENSOP - A DERIVATIVE-FREE SOLVER FOR NONLINEAR LEAST-SQUARES WITH SENSITIVITY SCALING, Annals of biomedical engineering, 21(6), 1993, pp. 621-631
Citations number
18
Categorie Soggetti
Engineering, Biomedical
ISSN journal
00906964
Volume
21
Issue
6
Year of publication
1993
Pages
621 - 631
Database
ISI
SICI code
0090-6964(1993)21:6<621:S-ADSF>2.0.ZU;2-A
Abstract
Nonlinear least squares optimization is used most often in fitting a c omplex model to a set of data. An ordinary nonlinear least squares opt imizer assumes a constant variance for all the data points. This paper presents SENSOP, a weighted nonlinear least squares optimizer, which is designed for fitting a model to a set of data where the variance ma y or may not be constant. It uses a variant of the Levenberg-Marquardt method to calculate the direction and the length of the step change i n the parameter vector. The method for estimating appropriate weightin g functions applies generally to 1-dimensional signals and can be used for higher dimensional signals. Sets of multiple tracer outflow dilut ion curves present special problems because the data encompass three t o four orders of magnitude; a fractional power function provides appro priate weighting giving success in parameter estimation despite the wi de range.