MORPHOLOGIC CHANGES OF THE LIVER FOLLOWING CHEMOTHERAPY FOR METASTATIC BREAST-CARCINOMA - CT FINDINGS

Thirty patients with metastatic breast carcinoma to the liver underwen t systemic chemotherapy. Twenty-four of these patients also received h epatic arterial infusion chemotherapy, three in conjunction with hepat ic artery embolization. The morphologic changes of the liver believed to be due to chemotoxic effect of treatment occurred in 27 patients, a nd were evaluated by serial computed tomography (CT) examinations. The se included fatty changes in seven patients, severe cirrhotic changes in four, localized atrophy with regional contour changes in three, and areas of low density in the regions of previously treated metastases in 13. The CT features of cirrhosis included density changes along wit h nodular irregularity of the hepatic borders with marked decrease in liver size and development of ascites.