Pk. Sanyal, PLASMA-LEVELS OF FENBENDAZOLE METABOLITES IN BUFFALO AND CATTLE AFTERLONG-TERM INTRARUMINAL ADMINISTRATION, Veterinary quarterly, 15(4), 1993, pp. 157-159
Plasma metabolite levels were measured in buffalo and cross-bred cattl
e after daily intraruminal administration of fenbendazole at 0.5 mg/kg
body weight. An equilibrium between the absorption of fenbendazole an
d disposition of its metabolites could be observed between days 3 to 6
and remained almost unchanged thereafter. The buffaloes had a lower u
ptake of the anthelmintic and lower plasma levels of its metabolites t
han in cattle. The findings were compared with those obtained after a
single intraruminal therapeutic dose of fenbendazole.