In an exploration of changes that occur with initiation of cocaine abs
tinence, this study examined treatment outcomes in four domains-behavi
or (cocaine use), affect (depression), cognition (schematic self-repre
sentations), and psychophysiology (reactivity to drug cues). Nineteen
patients initially entered this 8-week outpatient psychopharmacotherap
y trial for the treatment of cocaine dependence. Thirteen completed tr
eatment, and eleven maintained abstinence during the last four weeks o
f the study. In addition to a demonstrated change in their cocaine-usi
ng behavior, these ''abstainers'' reported reduced depression, increas
ed congruency with ''ideal'' self-schemas, increased discrepancy with
''addict'' self-schemas, and generally more positive self-representati
ons. In addition, ''abstainers'' reported reduced posttreatment cravin
g in the presence of cocaine cues, but evidenced no change in physiolo
gical reactivity. Implications of these findings for research and trea
tment are discussed.