EFFECTS OF PARTICLE-SIZE OF BULK DRUG AND FOOD ON THE BIOAVAILABILITYOF U-78875 IN DOGS

The effects of particle size and food on the absolute bioavailability of U-78875 in dogs after oral administration of either a suspension or tablet dosage form were investigated. A reduction of particle size ca used a significant increase in bioavailability along with an increase in dissolution rate. Additionally, both suspension and tablet dosage f orms administered after food caused an increase in bioavailability. Th us, to accelerate drug dissolution, a reduction of U-78875 particle si ze from the unmilled state is important for the optimization of formul ation compositions. To increase the bioavailability of U-78875, postpr andial dosing should be considered.