T. Nishihata et al., EFFECTS OF PARTICLE-SIZE OF BULK DRUG AND FOOD ON THE BIOAVAILABILITYOF U-78875 IN DOGS, Drug development and industrial pharmacy, 19(20), 1993, pp. 2679-2698
The effects of particle size and food on the absolute bioavailability
of U-78875 in dogs after oral administration of either a suspension or
tablet dosage form were investigated. A reduction of particle size ca
used a significant increase in bioavailability along with an increase
in dissolution rate. Additionally, both suspension and tablet dosage f
orms administered after food caused an increase in bioavailability. Th
us, to accelerate drug dissolution, a reduction of U-78875 particle si
ze from the unmilled state is important for the optimization of formul
ation compositions. To increase the bioavailability of U-78875, postpr
andial dosing should be considered.