DDAVP DOES NOT STIMULATE ACUTE CHANGES IN LEVELS OF MEDULLARY TRIMETHYLAMINES IN HUMANS

H-1 nuclear magnetic resonance has been used to determine the effect o f acute iv administration of the arginine vasopressin analog 1-(3-merc aptopropionic acid)-8-D-arginine vasopressin monoacetate (ddAVP; 2 mug ) on renal medullary trimethylamine (TMA) levels in human volunteers. In subjects deprived of food and water for 15 h, urine osmolality (U(o sm)) was 889 +/- 47 mosmol/kg and had not changed significantly 3 h af ter ddAVP administration. Medullary TMA did not change significantly o ver 3 h after ddAVP. In a second group of subjects who were well hydra ted, acute ddAVP infusion increased U(osm) from 203 +/- 63 to 421 +/- 47 mosmol/kg in 3 h (P < 0.05). However, medullary TMA did not change significantly over this time period. These results indicate that ddAVP , and presumably arginine vasopressin, do not acutely influence medull ary TMA levels, and they support the view that results previously repo rted for animal and isolated cell systems are also applicable to human physiology.