EFFECT OF PHENCYCLIDINE ON ENDOGENEOUS EXCITATORY AMINO-ACID RELEASE FROM THE RAT ANTERIOR CINGULATE CORTEX - AN IN-VIVO MICRODIALYSIS STUDY

Authors
YONEZAWA Y HONDO H HASHIMOTO K MATSUMOTO T HIRANO M UCHIMURA H KUROKI T
Citation
Y. Yonezawa et al., EFFECT OF PHENCYCLIDINE ON ENDOGENEOUS EXCITATORY AMINO-ACID RELEASE FROM THE RAT ANTERIOR CINGULATE CORTEX - AN IN-VIVO MICRODIALYSIS STUDY, Journal of neural transmission, 94(3), 1993, pp. 235-240
Citations number
23
Categorie Soggetti
Neurosciences
Journal title
Journal of neural transmission → ACNP
ISSN journal
03009564
Volume
94
Issue
3
Year of publication
1993
Pages
235 - 240
Database
ISI
SICI code
0300-9564(1993)94:3<235:EOPOEE>2.0.ZU;2-0
Abstract
The effect of systemically administered phencyclidine (PCP) on the ext racellular concentration of aspartate (Asp) and glutamate (Glu) in the rat anterior cingulate cortex was investigated using in vivo microdia lysis. PCP significantly reduced the K+-evoked release of Asp and Glu, while it had no effect on the basal efflux of Asp and Glu. These resu lts suggest that PCP might inhibit excitatory amino acid (EAA) release through an N-methyl-D-aspartate (NMDA) receptor-mediated mechanism.