DEGRADATION PRODUCTS OF STREPTOZOTOCIN DO NOT INDUCE HYPERGLYCEMIA INRATS

Authors
LEE JY KIM MJ MOON CK CHUNG JH
Citation
Jy. Lee et al., DEGRADATION PRODUCTS OF STREPTOZOTOCIN DO NOT INDUCE HYPERGLYCEMIA INRATS, Biochemical pharmacology, 46(11), 1993, pp. 2111-2113
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
Biochemical pharmacology → ACNP
ISSN journal
00062952
Volume
46
Issue
11
Year of publication
1993
Pages
2111 - 2113
Database
ISI
SICI code
0006-2952(1993)46:11<2111:DPOSDN>2.0.ZU;2-Q
Abstract
The present study was conducted to determine whether degradation produ cts of streptozotocin formed under various conditions induce hyperglyc emia in rats. Streptozotocin is completely degraded in pH 7.4 buffer i n 4 hr and even more rapidly plasma. Streptozotocin degradation produc ts resulting from incubation in pH 7.4 phosphate buffer or in plasma w ere not diabetogenic in rats.