A STUDY ON THE ANTIGENIC NATURE OF CIRCULATING IMMUNE-COMPLEXES IN HEMOLYTIC-UREMIC SYNDROME - NO EVIDENCE OF PLATELET MEMBRANE GLYCOPROTEIN ANTIGENS

Authors
OLAVARRIA F PEREIRA J MEZZANO S KUNICK M CASTILLO A
Citation
F. Olavarria et al., A STUDY ON THE ANTIGENIC NATURE OF CIRCULATING IMMUNE-COMPLEXES IN HEMOLYTIC-UREMIC SYNDROME - NO EVIDENCE OF PLATELET MEMBRANE GLYCOPROTEIN ANTIGENS, Nephron, 66(1), 1994, pp. 58-61
Citations number
25
Categorie Soggetti
Urology & Nephrology
Journal title
Nephron → ACNP
ISSN journal
00282766
Volume
66
Issue
1
Year of publication
1994
Pages
58 - 61
Database
ISI
SICI code
0028-2766(1994)66:1<58:ASOTAN>2.0.ZU;2-W
Abstract
Circulating immune complexes (CIC) have been described in the hemolyti c uremic syndrome (HUS) in children. They may represent an epiphenomen on or could be related to the platelet activation and endothelial dama ge observed in this disease. In an attempt to define this relationship , we investigated the CIC isolated in 17 patients with the classic for m of HUS, by means of monoclonal antibodies against platelet surface g lycoprotein Ib and IIb-IIIa complex. The negative results obtained do not support the possibility of platelet antigens being constituents of CIC and make an antibody-induced platelet activation in HUS very unli kely.