TREATMENT OF RECURRENT UNCOMPLICATED LOWE R URINARY-TRACT INFECTION IN WOMEN - LOMEFLOXACIN VERSUS NORFLOXACIN

Objective : compare the acceptability of 3-day regimen with that of 10 -day regimen of fluoroquinolones for the treatment of recurrent uncomp licated lower urinary tract infection in women. Methods : a multicentr ic, randomized open trial was conduced in 421 patients by gynecologic and general practitioners to determine acceptability, efficacy and saf ety of lomefloxacin 400 mg in a once a day dose given for three days c ompared with norfloxacin 800 mg in twice a day dose given for ten days for the treatment of recurrent uncomplicated lower urinary tract infe ction in women. Results : acceptability assessed at day 14, was signif icantly better for lomefloxacin group than norfloxacin group, respecti vely 57, 1 p. 100 and 38,0 p. 100. Clinical success rate at day 14 was 97,2 p. 100 for lomefloxacin and 97,5 p. 100 for norfloxacin; at day 30 clinical success rate was respectively 97,6 p. 100 and 98, 1 p. 100 relapse at one year was comparable between two groups. Adverse events were reported respectively in 15,6 p. 100 and 16,6 p. 100 of the pati ents, vaginal infections, dermatologic disorders and digestive disorde rs (abdominal pain, nausea) predominated There were no serious adverse event. Conclusion : the acceptability is better for a 3-day regimen o f lomefloxacin than a 10-day regimen of norfloxacin for treatment of r ecurrent uncomplicated lower urinary tract infection in women for comp arable efficacy and safety.