ENDOTHELIN-3 INCREASES TRANSMISSION IN THE RABBIT PULMONARY PARASYMPATHETIC NERVOUS-SYSTEM

Citation
Ko. Mckay et al., ENDOTHELIN-3 INCREASES TRANSMISSION IN THE RABBIT PULMONARY PARASYMPATHETIC NERVOUS-SYSTEM, Journal of cardiovascular pharmacology, 22, 1993, pp. 190000181-190000184
Citations number
11
Categorie Soggetti
Cardiac & Cardiovascular System","Respiratory System","Pharmacology & Pharmacy
ISSN journal
01602446
Volume
22
Year of publication
1993
Supplement
8
Pages
190000181 - 190000184
Database
ISI
SICI code
0160-2446(1993)22:<190000181:EITITR>2.0.ZU;2-F
Abstract
The effect of endothelin-3 (ET-3) on the response to parasympathetic n erve stimulation of rabbit isolated bronchus was examined. The site of action of ET-3 in the pulmonary parasympathetic nervous system was al so investigated. ET-3 induced a concentration-dependent increase in th e response to electrical field stimulation. The response was atropine sensitive and therefore cholinergically mediated. At a concentration o f 10 nM, ET-3 increased the response to field stimulation to 205 +/- 4 2% of the initial response. The effect was concentration-related, as 1 00 nM further increased this response to 315 +/- 69%. The responsivene ss of the tissue to exogenous acetylcholine was not affected by ET-3. Therefore ET-3 has a neuromodulatory role on cholinergic parasympathet ic transmission in rabbit airways exerted at a prejunctional site.