NEW ANTINEOPLASTIC AZA-PHOSPHOLIPIDS - SYNTHESIS, IN-VITRO CYTOTOXICITY AND DIFFERENTIAL CELLULAR-SENSITIVITY AGAINST 70 HUMAN TUMOR-CELL LINES

The in vitro cytotoxicity and differential cellular sensitivity of thr ee new synthetic anti-neoplastic aza-phospholipids has been determined in the National Cancer Institute's (NCI) primary antitumor drug scree n. Based on a disease-oriented strategy, this screen incorporates seve nty human cell lines representing leukemia, ovarian, brain, melanoma, colon, renal, lung, prostate and breast cancers. The analysis of the G I50 values obtained for each aza-derivative has revealed a differentia l cellular sensitivity among the cell lines examined. The study of the degree of differential growth inhibition has shown a statistically si gnificant differential cell sensitivity for BN 52205 and BN 52211 for colon and melanoma tumor cells. The leukemia cell selectivity for BN 5 2211 was even more remarkable due to the low molar concentration at wh ich the maximum selective effect occurred. These findings strongly enc ourage further investigations on the anti-neoplastic activity of aza-p hospholipids.