T. Lai et al., P-GLYCOPROTEIN EXPRESSION, TUMOR DIFFERENTIATION, CHEMOSENSITIVITY OFTUMOR-CELLS IN-VITRO AND CLINICAL OUTCOME IN PATIENTS WITH RENAL-CELLCARCINOMA, International journal of oncology, 4(1), 1994, pp. 211-213
There was no association between expression of P-170 glycoprotein on c
ells derived from 14 renal carcinomas and the in vitro sensitivity of
the cells to doxorubicin or its potentiation by verapamil. Furthermore
expression of P-170 on the cells of individual tumours was unrelated
to nuclear differentiation or patient prognosis. These observations ma
y in part resolve the dilemma posed by the reported association in som
e tumour types between expression of P-170 and the metastatic phenotyp
e together with the previously observed relation in renal carcinoma be
tween P-170 expression, good tumour differentiation and therefore a fa
vourable prognosis.