PROSTACYCLINS IN DIABETES - AN ELECTROPHYSIOLOGICAL STUDY

Twelve patients with juvenile (insulin-dependent, type I) diabetes wer e treated either with prostacyclins or placebo in a double-masked rand omized study. The electroretinogram (ERG) was recorded before, 1 day a nd 8 months after treatment. An analysis of variance and covariance wa s carried out to evaluate possible treatment or time effects on the a and b waves and the oscillatory potentials of the ERG. Mean values of potentials displayed a decrease of amplitude and an increase of latenc y over the follow-up period in all patients. No statistically signific ant difference between treated and placebo groups could be proven.