Congenital symmetrical interdigital hyperkeratosis is a rare disorder
described by Frei in 1923, characterized by localized hyperkeratosis o
f the interdigital spaces of the hands and feet. The authors report th
e case of a 7-year-old girl affected by this condition. The skin hyper
keratotic lesions appeared localized exclusively to the interdigital s
paces of the hands. Histologic examination showed orthokeratotic hyper
keratosis, hypergranulosis and acanthosis. Keratolytics failed to impr
ove the clinical picture.