THE 5'-HYDROGEN PHOSPHONATE ANALOG AS A POTENTIAL PRODRUG OF 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE (AZT)

Authors
BOAL JH IYER RP EGAN W
Citation
Jh. Boal et al., THE 5'-HYDROGEN PHOSPHONATE ANALOG AS A POTENTIAL PRODRUG OF 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE (AZT), Nucleosides & nucleotides, 12(10), 1993, pp. 1075-1084
Citations number
19
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
12
Issue
10
Year of publication
1993
Pages
1075 - 1084
Database
ISI
SICI code
0732-8311(1993)12:10<1075:T5PAAA>2.0.ZU;2-4
Abstract
A novel synthesis of AZT-5'-H-phosphonate 2, involving decarboxylation of the phosphonoformate intermediate 7, is reported herein. Studies o f the metabolism of 2 in U937 cells indicate that 2 is readily convert ed to AZT-5'-monophosphate.