SYNTHESIS OF NEW PENEM DITHIOCARBAMATES

Authors
ALTAMURA M GIANNOTTI D PERROTTA E SBRACI P PESTELLINI V ARCAMONE FM SATTA G
Citation
M. Altamura et al., SYNTHESIS OF NEW PENEM DITHIOCARBAMATES, Bioorganic & medicinal chemistry letters, 3(11), 1993, pp. 2159-2164
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
11
Year of publication
1993
Pages
2159 - 2164
Database
ISI
SICI code
0960-894X(1993)3:11<2159:SONPD>2.0.ZU;2-K
Abstract
Penem dithiocarbamates 10 were synthesized from the alcohol 6, in high yields and favourable ratio between the penem and the undesired penam isomers. In vitro antibacterial activity showed a dependence on polar ity and steric hindrance of the side chain at C-2. Best results were o btained with the piperazino derivatives 10 l-n, while catechol 10 p di d not show the expected improvements in anti-pseudomonal activity.