PENEMS CONTAINING AMINO-ACID DERIVED SUBSTITUENTS AT C-2

Authors
AFONSO A HON F WEINSTEIN J GENTLES M SHAPIRO ES GANGULY AK NAPLES L HARE RS MILLER GH
Citation
A. Afonso et al., PENEMS CONTAINING AMINO-ACID DERIVED SUBSTITUENTS AT C-2, Bioorganic & medicinal chemistry letters, 3(11), 1993, pp. 2177-2182
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
11
Year of publication
1993
Pages
2177 - 2182
Database
ISI
SICI code
0960-894X(1993)3:11<2177:PCADSA>2.0.ZU;2-I
Abstract
Several penems of types I - IV containing side-chains at C-2 derived f rom D-or L-amino acids were synthesized. The in-vitro antibacterial sp ectrum of these compounds is influenced by the stereochemistry of the side-chain. In general, penems with side-chains derived from D-amino a cids are more potent, particularly against gram-negative organisms, re lative to the isomeric analogs.