N-ACYL 3-ALKYLIDENYL AZETIDIN-2-ONES AND 3-ALKYL AZETIDIN-2-ONES - A NEW CLASS OF MONOCYCLIC BETA-LACTAM ANTIBACTERIAL AGENTS .2. SYNTHESISANDST RUCTURE-ACTIVITY RELATIONSHIPS OF HETEROATOM SUBSTITUTED 3-ISOPROPYLIDENE A ND 3-ISOPROPYL ANALOGS

Authors
BRICKNER SJ GAIKEMA JJ GREENFIELD LJ ZURENKO GE MANNINEN PR
Citation
Sj. Brickner et al., N-ACYL 3-ALKYLIDENYL AZETIDIN-2-ONES AND 3-ALKYL AZETIDIN-2-ONES - A NEW CLASS OF MONOCYCLIC BETA-LACTAM ANTIBACTERIAL AGENTS .2. SYNTHESISANDST RUCTURE-ACTIVITY RELATIONSHIPS OF HETEROATOM SUBSTITUTED 3-ISOPROPYLIDENE A ND 3-ISOPROPYL ANALOGS, Bioorganic & medicinal chemistry letters, 3(11), 1993, pp. 2241-2246
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
11
Year of publication
1993
Pages
2241 - 2246
Database
ISI
SICI code
0960-894X(1993)3:11<2241:N3AA3A>2.0.ZU;2-L
Abstract
O-, N-, or F-substituted 3-isopropylidene- and 3-isopropyl N-acyl azet idin-2-ones, lacking an ionizable moiety attached to the lactam nitrog en, have in vitro antibacterial activity, being particularly potent vs anaerobes.