SYNTHESIS AND BETA-LACTAMASE INHIBITORY ACTIVITY OF 6-HYDROXYETHYL THIACLAVULANIC ACID

Authors
CABRI W BEDESCHI A PERRONE E VISENTIN G JABES D FRANCESCHI G
Citation
W. Cabri et al., SYNTHESIS AND BETA-LACTAMASE INHIBITORY ACTIVITY OF 6-HYDROXYETHYL THIACLAVULANIC ACID, Bioorganic & medicinal chemistry letters, 3(11), 1993, pp. 2255-2258
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
11
Year of publication
1993
Pages
2255 - 2258
Database
ISI
SICI code
0960-894X(1993)3:11<2255:SABIAO>2.0.ZU;2-P
Abstract
6-Hydroxyethyl thiaclavulanic acid, possessing the ''natural'' configu ration both at C3 and at the double bond, was synthesized in only two steps from the penem nucleus via a palladium catalysed vinyl epoxide r eductive rearrangement. The beta-lactamase inhibitory activity is repo rted.