INHIBITION OF HUMAN-LEUKOCYTE ELASTASE .5. INHIBITION BY 6-ALKYL SUBSTITUTED PENEM BENZYL-ESTERS

Authors
FINKE PE DAHLGREN ME WESTON H MAYCOCK AL DOHERTY JB
Citation
Pe. Finke et al., INHIBITION OF HUMAN-LEUKOCYTE ELASTASE .5. INHIBITION BY 6-ALKYL SUBSTITUTED PENEM BENZYL-ESTERS, Bioorganic & medicinal chemistry letters, 3(11), 1993, pp. 2277-2282
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
11
Year of publication
1993
Pages
2277 - 2282
Database
ISI
SICI code
0960-894X(1993)3:11<2277:IOHE.I>2.0.ZU;2-K
Abstract
Penem benzyl esters substituted at the 6-position with small alkyl gro ups and at the 3-position with a variety of carbon and heteroatom grou ps were prepared as inhibitors of human leukocyte elastase (HLE). The structure activity relations found for the these positions are discuss ed in relation to known cephalosporin inhibitors and some important st ereochemical implications are reported for inhibition of HLE by these beta-lactam structures.