INHIBITION OF HUMAN-LEUKOCYTE ELASTASE .6. INHIBITION BY 6-SUBSTITUTED PENICILLIN ESTERS

Authors
THOMPSON KR FINKE PE SHAH SK ASHE BM DAHLGREN ME MAYCOCK AL DOHERTY JB
Citation
Kr. Thompson et al., INHIBITION OF HUMAN-LEUKOCYTE ELASTASE .6. INHIBITION BY 6-SUBSTITUTED PENICILLIN ESTERS, Bioorganic & medicinal chemistry letters, 3(11), 1993, pp. 2283-2288
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
11
Year of publication
1993
Pages
2283 - 2288
Database
ISI
SICI code
0960-894X(1993)3:11<2283:IOHE.I>2.0.ZU;2-L
Abstract
Penicillin esters substituted at C-6 with a variety of functionalities are reported as human leukocyte elastase (HLE) inhibitors. The struct ure activity relations for die esters and C-6 derivatives are discusse d and compared to the known cephalosporin structures.