SYNTHESIS OF BETA-LACTAMS OF HIGH ENANTIOMERIC PURITY BY CHIRAL LIGAND ACCELERATED OSMYLATION OF RACEMIC 4-(2-STYRYL)-AZETIDIN-2-ONES

Authors
ANNUNZIATA R BENAGLIA M CINQUINI M COZZI F PONZINI F
Citation
R. Annunziata et al., SYNTHESIS OF BETA-LACTAMS OF HIGH ENANTIOMERIC PURITY BY CHIRAL LIGAND ACCELERATED OSMYLATION OF RACEMIC 4-(2-STYRYL)-AZETIDIN-2-ONES, Bioorganic & medicinal chemistry letters, 3(11), 1993, pp. 2397-2402
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
11
Year of publication
1993
Pages
2397 - 2402
Database
ISI
SICI code
0960-894X(1993)3:11<2397:SOBOHE>2.0.ZU;2-A
Abstract
The catalytic osmylation of a series of 4-(2-styryl)-azetidin-2-ones c arried out in the presence of dihydroquinidine-p-chlorobenzoate opens access to synthetically useful precursors of beta-lactam antibiotics o f high enantiomeric purity (ee up to 97%).