BETA-LACTAMS FROM CHIRALLY-ENRICHED (ALLENYLMETHYL)SILANES

Authors
COLVIN EW KONIG WA LORETO MA ROWDEN JY TOMMASINI I
Citation
Ew. Colvin et al., BETA-LACTAMS FROM CHIRALLY-ENRICHED (ALLENYLMETHYL)SILANES, Bioorganic & medicinal chemistry letters, 3(11), 1993, pp. 2405-2408
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
11
Year of publication
1993
Pages
2405 - 2408
Database
ISI
SICI code
0960-894X(1993)3:11<2405:BFC(>2.0.ZU;2-U
Abstract
Functionalised (allenylmethyl)silanes react with chlorosulphonyl isocy anate in a highly regioselective manner to provide beta-lactams with t he side-chain functionality of the asparenomycins. Chirally enriched ( allenylmethyl)silanes transfer their axial chirality to the carbon-cen tred chirality in the product beta-lactams.