THE SYNTHESIS OF 3-AMINO-2,3-DIDEOXY-2-FLUORO-XYLOSES FROM A 3-FLUOROAZETIDINONE

Authors
ARAKI K OTOOLE JC WELCH JT
Citation
K. Araki et al., THE SYNTHESIS OF 3-AMINO-2,3-DIDEOXY-2-FLUORO-XYLOSES FROM A 3-FLUOROAZETIDINONE, Bioorganic & medicinal chemistry letters, 3(11), 1993, pp. 2457-2460
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
11
Year of publication
1993
Pages
2457 - 2460
Database
ISI
SICI code
0960-894X(1993)3:11<2457:TSO3FA>2.0.ZU;2-Z
Abstract
Optically active imethyl-2',4'-dioxol-1-yl)-3-fluoro-2-azetidinone, pr epared by the ketene-imine cycloaddition method, is a convenient build ing block for asymmetric synthesis. This beta-lactam has been transfor med into imethylsilyl)2,3-dideoxy-2-fluoro-3-(4-methoxyphen yl)amino-D -xylo-pentafuranose and the gentosamine analog, etyl-2,3-dideoxy-2-flu oro-3-)4-methoxyphenyl)amino D-xylo-pentapyranose.