N-ACYL-3-HYDROXY-BETA-LACTAMS AS KEY INTERMEDIATES FOR TAXOTERE AND ITS ANALOGS

Authors
OJIMA I ZUCCO M DUCLOS O KUDUK SD SUN CM PARK YH
Citation
I. Ojima et al., N-ACYL-3-HYDROXY-BETA-LACTAMS AS KEY INTERMEDIATES FOR TAXOTERE AND ITS ANALOGS, Bioorganic & medicinal chemistry letters, 3(11), 1993, pp. 2479-2482
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
11
Year of publication
1993
Pages
2479 - 2482
Database
ISI
SICI code
0960-894X(1993)3:11<2479:NAKIFT>2.0.ZU;2-Q
Abstract
(3R,4S)-3-(protected hydroxy)-4-substituted beta-lactams bearing N-alk oxycarbonyl, N-aryloxycarbonyl, and N-carbamoyl groups are found to be useful for the syntheses of taxotere and its analogs through coupling with baccatin III.