Recurrent urticaria/anaphylaxis is a most perplexing and critical prob
lem, often of unknown cause. Though difficult and time consuming, iden
tification of causes(s) can be life saving and cost saving for the pat
ient(s). We report a complex case of urticaria/anaphylaxis induced by
latex allergen in a former intensive care unit nurse, in which the all
ergen contact occurred remotely and indirectly by intimate contact wit
h the spouse. Diagnosis of the latex allergy was confirmed by epicutan
eous skin test in vivo as well as RAST.