EFFECTS OF HOST IMMUNITY ON HEPATIC METASTASIS - RELATIONSHIP BETWEENEFFECTS OF MITOMYCIN-C (MMC) AND OK-432 ON IMMUNITY AND HEPATIC METASTASIS IN AN EXPERIMENTAL-MODEL
S. Katsuyama et al., EFFECTS OF HOST IMMUNITY ON HEPATIC METASTASIS - RELATIONSHIP BETWEENEFFECTS OF MITOMYCIN-C (MMC) AND OK-432 ON IMMUNITY AND HEPATIC METASTASIS IN AN EXPERIMENTAL-MODEL, Journal of experimental & clinical cancer research, 12(4), 1993, pp. 241-247
The effects of MMC and/or OK-432 on host immunity were studied using a
hepatic metastatic model. AH60C cells, which have sensitivity to MMC
on the SDI test in vitro, were inoculated before or after administrati
on of MMC to the portal vein. The number of hepatic metastases increas
ed in both groups. Administration of OK-432 decreased the number of he
patic metastases and that of MMC+OK-432 decreased more markedly. The a
dministration of MMC decreased the NK activity in the liver, but OK-43
2 improved the hepatic NK activity to the level of the AH60C group and
the administration of MMC+OK-432 increased the hepatic NK activity mo
re than the OK-432 group alone. The administration of MMC+OK-432 induc
ed stronger NK activity than that of the OK-432 alone even at the dose
of MMC, that decreased the NK activity. This suggested an interaction
between MMC and OK-432. Since anticancer agents that show sensitivity
to tumors can sometimes induce hepatic metastasis with the dose of an
ticancer unbalancing the host immunity, a good method is then required
to monitor the host immunity in chemotherapy. The proper combination
between anticancer agents and biological response modifiers which indu
ce host immunity is not to be neglected in chemotherapy.