S. Ramaprasad et al., RESPONSES TO PHOTODYNAMIC THERAPY IN A MURINE TUMOR-MODEL - P-31 NMR AND WATER PROTON RELAXATION STUDIES, Journal of environmental science and health. Part A: Environmental science and engineering, 28(10), 1993, pp. 2345-2357
In this study we report the tumor responses to photodynamic therapy (P
DT) as measured by in vivo P-31 NMR and water relaxation measurements
on a murine tumor model. We evaluate the POT responses to two new phot
osensitizers by monitoring the tumor volumes post PDT forone tumor and
by in vivo P-31 NMR for the other. Both photosensitizers are structur
ally well defined, pure compounds, unlike Photofrin II (PF II), which
is a complex chemical mixture of a variety of porphyrin species. Drama
tic increases in inorganic phosphate (P-1) wereollowing PDT treatment.
The tumor water relaxation time measurements also suggest correspondi
ng increases in T-1 values after PDT treatment. From a combined study
of relaxation times, P-31 NMR, and tumor volumes, we conclude that the
relaxation measurements can serve as a useful and sensitive method of
monitoring PDT.