REM-SLEEP DEPRIVATION POTENTIATES THE EFFECTS OF IMIPRAMINE AND DESIPRAMINE BUT NOT THAT OF CLOMIPRAMINE IN THE FORCED SWIMMING TEST

Citation
W. Asakura et al., REM-SLEEP DEPRIVATION POTENTIATES THE EFFECTS OF IMIPRAMINE AND DESIPRAMINE BUT NOT THAT OF CLOMIPRAMINE IN THE FORCED SWIMMING TEST, Japanese Journal of Pharmacology, 63(4), 1993, pp. 455-460
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
00215198
Volume
63
Issue
4
Year of publication
1993
Pages
455 - 460
Database
ISI
SICI code
0021-5198(1993)63:4<455:RDPTEO>2.0.ZU;2-K
Abstract
Effects of REM sleep (REMs) deprivation on the basal swimming activity and the tricyclic antidepressants-induced increase in swimming activi ty in the forced swimming test were investigated. Immediately after a 48-hr period of REMs deprivation, the basal swimming activity in REMs- deprived mice was significantly higher than those in group-housed and socially isolated animals used as the control groups. The REMs depriva tion-induced increase in the swimming activity was not changed by adre noceptor antagonists and it returned to the control levels 3 hr after the REMs deprivation treatment. Moreover, imipramine and desipramine b ut not clomipramine further increased the swimming activity enhanced b y REMs deprivation at doses that did not affect the activity in the co ntrol groups. The enhancing effect of REMs deprivation on the sensitiv ity to imipramine and desipramine remained unchanged even at 3 hr afte r the REMs deprivation treatment, and it was blocked by the alpha(2)-a drenoceptor antagonist yohimbine. These results suggest that the REMs deprivation-induced increase in basal swimming activity in the forced swimming test is not mediated by adrenoceptor mechanisms, whereas the enhancing effect of REMs deprivation on the sensitivity to imipramine and desipramine may be mediated by the functional changes in alpha(2)- adrenoceptors in the brain.