PLATELET-RICH PLASMA SEROTONIN LEVELS IN TENSION-TYPE HEADACHE AND DEPRESSION

We measured platelet-rich plasma (PRP) serotonin in patients suffering from tension-type headache, before and after treatment with amitripty line, comparing them with a healthy control group and patients with un treated depression. We evaluated the severity of headache and depressi on in each group. PRP serotonin levels were higher in patients with he adache than in controls and depressed patients. We observed a fall of PRP serotonin in patients with tension-type headache to similar levels after treatment as the depressed group. This fall was correlated with the improvement of headache but not with depression scales. Our data suggest that the rise of platelet serotonin levels in tension-type hea dache is related to pain and not depression.