MAJOR HISTOCOMPATIBILITY COMPLEX GENES AND SUSCEPTIBILITY TO SYSTEMICLUPUS-ERYTHEMATOSUS IN NORTHERN INDIA

Authors
MEHRA NK PANDE I TANEJA V UPPAL SS SAXENA SP KUMAR A MALAVIYA AN
Citation
Nk. Mehra et al., MAJOR HISTOCOMPATIBILITY COMPLEX GENES AND SUSCEPTIBILITY TO SYSTEMICLUPUS-ERYTHEMATOSUS IN NORTHERN INDIA, Lupus, 2(5), 1993, pp. 313-314
Citations number
22
Categorie Soggetti
Medicine, General & Internal",Rheumatology
Journal title
Lupus → ACNP
ISSN journal
09612033
Volume
2
Issue
5
Year of publication
1993
Pages
313 - 314
Database
ISI
SICI code
0961-2033(1993)2:5<313:MHCGAS>2.0.ZU;2-#
Abstract
Fifty-eight patients with systemic lupus erythematosus (SLE) from Nort hern India were tissue typed for HLA class I and II antigens. The resu lts revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8- DR3 was encountered frequently in the patient group. The findings sugg est an important role of MHC genes in influencing susceptibility to SL E.