One hundred and fifty-five eyes (106 cases) affected by preproliferati
ve diabetic retinopathy were divided into three subgroups according to
the severity of retinopathy and were followed for one year. The crite
ria for and numbers of eyes in each group were as follows: 1) mild typ
e with soft exudates and without apparent nonperfused areas on fluores
cein angiography (39 eyes), 2) moderate type with soft exudates and de
monstrable nonperfused areas (103 eyes), 3) severe type with soft exud
ates, nonperfused areas and venous beading (13 eyes). The proportion u
ndergoing photocoagulation was 23% in the mild type, 81% in the modera
te type and 100% in the severe type. None of the mild type eyes underw
ent photocoagulation unless they advanced to a more severe type. Nine
of the mild type eyes which progressed to moderate type during the fol
low-up period underwent focal photocoagulation. Panretinal photocoagul
ation was performed in 29% of moderate type eyes and 77% of severe typ
e eyes. The courses of these three subgroups were analyzed after one y
ear of follow-up. The proportion developing proliferative retinopathy
was 0% in the mild type, 18% in the moderate type and 46% in the sever
e type. Based on the above results, it was concluded that the subclass
ification we proposed in this paper can be applied to the management o
f patients with preproliferative diabetic retinopathy.