FORMATION OF A STRUCTURAL ISOMER OF PLATE LET-ACTIVATING-FACTOR DURING 1-ALKYL-SN-GLYCERO-3-PHOSPHOCHOLINE ACETYLATION

Authors
CHUPIN VV OSTAPENKO OV KLYKOV VN ANIKIN MV SEREBRENNIKOVA GA
Citation
Vv. Chupin et al., FORMATION OF A STRUCTURAL ISOMER OF PLATE LET-ACTIVATING-FACTOR DURING 1-ALKYL-SN-GLYCERO-3-PHOSPHOCHOLINE ACETYLATION, Bioorganiceskaa himia, 19(11), 1993, pp. 1111-1121
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
19
Issue
11
Year of publication
1993
Pages
1111 - 1121
Database
ISI
SICI code
0132-3423(1993)19:11<1111:FOASIO>2.0.ZU;2-L
Abstract
In studying acetylation of 1-alkyl-sn-glycero-3-phosphocholine (lyso P AF) with acetic anhydride, a key step of the platelet activating facto r (PAF) synthesis, we have found that in the presence of triethylamine or 4-dimethylaminopyridine some 1-alkyl-3-acetyl-sn-glycero-2-phospho choline as an admixtute to PAF formed, whereas the acid catalysed reac tion resulted in isomerically pure PAF. The mechanism of the reaction leading to the PAF structural isomer is discussed.