SYNTHESIS AND ANTIGENIC ACTIVITY OF THE P EPTIDES FROM THE HEPATITIS-C VIRUS NS4-PROTEIN C-TERMINAL REGION

Authors
SEMILETOV YA FIRSOVA TV KUZIN SN KHUDYAKOV YE SHIBNEV VA
Citation
Ya. Semiletov et al., SYNTHESIS AND ANTIGENIC ACTIVITY OF THE P EPTIDES FROM THE HEPATITIS-C VIRUS NS4-PROTEIN C-TERMINAL REGION, Bioorganiceskaa himia, 19(11), 1993, pp. 1128-1131
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
19
Issue
11
Year of publication
1993
Pages
1128 - 1131
Database
ISI
SICI code
0132-3423(1993)19:11<1128:SAAAOT>2.0.ZU;2-#
Abstract
A set of four peptides from the HCV NS4-protein C-terminal region (aa 1921-1940) were obtained by solid-phase synthesis using activated este rs and symmetrical anhydrides of Boc-amino acids. Peptide 1921-1940 ha s demonstrated a positive reaction in ELISA with individual anti-HCV-p ositive sera from patients with acute and chronic hepatitis C (80% and 56%, respectively). We analysed the antigenic properties of the pepti de 1921-1940 and its fragments and suggested at least two antibody rec ognizing sites to be contained in this region.