THE ACUTE EFFECTS OF PANCREATICOPYELOSTOMY ON THE PANCREAS AND KIDNEY- A PRELIMINARY-STUDY

A modified canine pancreaticopyelostomy model with an intact kidney wa s constructed. The effects of this procedure on the pancreas and kidne y were examined in five dogs by monitoring the serum and urine levels of pH, bicarbonate, chloride, glucose, urea, creatinine and amylase in 24-h periods for up to 72 h. The contralateral kidney served as contr ols. The pancreas and kidney were removed and examined under light mic roscopy after the animals were sacrificed. Both of the organs had main tained their normal histological architecture. The serum and urine glu cose levels were consistent with a normal response after the initial e levation immediately following the surgical trauma. The urine urea con centrations from both kidneys were similar, as were the creatinine exc retion trends throughout the 72 h, except for a significant rise in th e creatinine excretion on the pancreaticopyelostomy side at 24 h. The pH, bicarbonate, chloride, and amylase values revealed a normal and fu nctioning exocrine pancreas. It is concluded from this preliminary stu dy that pancreaticopyelostomy with an intact kidney does not have acut e adverse effects, either on the pancreas or on the kidney. This proce dure may be an alternative method for pancreatic exocrine drainage if similar results are obtained in chronic models.